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IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the medication is safe, appropriate, or effective for you. Consult your healthcare professional before using Zocor.

ZOCOR DESCRIPTION: SIMVASTATIN - ORAL (SIM-vuh-stat-in)

COMMON ZOCOR BRAND NAME(S): Zocor

What is Zocor

Zocor is a prescription medication used, along with a cholesterol-lowering diet, to help lower cholesterol and fats (triglycerides) in the blood. Reducing cholesterol and triglycerides helps prevent strokes and heart attacks.

How to Take Zocor

Take Zocor by mouth usually once daily in the evening, with or without food. Certain medical conditions (e.g., familial hypercholesterolemia) may require more frequent dosage instructions as directed by your doctor. Dosage is based on your medical condition, response to therapy, and use of certain interacting medicines. Consult your doctor or pharmacist for more details, since many of the medications listed in the Medication Interactions section may increase the chances of muscle injury when used with Zocor. It may take up to 4 weeks before the full benefit of Zocor takes effect. It is important to continue taking Zocor even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

Zocor Side Effects

Headache, nausea, diarrhea, constipation, gas, or stomach upset/pain may occur. If any of these effects persist or worsen, notify your doctor promptly.

Tell your doctor immediately if any of these unlikely but serious side effects occur: joint pain, muscle pain or weakness, fever, unusual tiredness, chest pain, swelling in the arms or legs, dizziness. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes and skin, dark urine, change in amount of urine, black stool, severe stomach pain. An allergic reaction to Zocor is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Zocor Precautions

Zocor is not recommended for use if you have the following medical conditions: liver problems. Tell your doctor your medical history, especially of: heart disease, kidney problems, thyroid problems, uncontrolled seizures, recent serious infection, recent major surgery, low blood pressure, alcohol use, any allergies (especially to other "statin" medications). Daily use of alcohol may increase your chance for serious side effects. Limit alcoholic beverages. Zocor must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is recommended that women of child-bearing age use effective birth control measures while taking Zocor since simvastatin may cause fetal harm. It is not known whether Zocor passes into breast milk. Because of the potential risk to the infant, breast-feeding while using Zocor is not recommended. Consult your doctor before breast-feeding.

Zocor Medication Interactions

Zocor should not be used with the following medications because very serious, possibly fatal interactions may occur: mibefradil, HIV protease inhibitors (e.g., ritonavir, amprenavir, lopinavir), azole antifungals (e.g., itraconazole, ketoconazole), macrolide antibiotics (e.g., clarithromycin, erythromycin, troleandomycin), nefazodone. Ask your doctor or pharmacist for more details. Use caution if the following medications are combined with simvastatin because serious side effects such as muscle injury (myopathy) infrequently could occur: fibrates (e.g., gemfibrozil, fenofibrate), high-dose niacin (1 gram or more per day). Tell your doctor of all and non medication you may use, especially: amiodarone, colestipol, cholestyramine, cyclosporine, digoxin, verapamil, "blood thinners" (e.g., warfarin), diltiazem, rifamycins (e.g., rifampin), medications which decrease liver metabolism (inhibitors of cytochrome 3A4 enzymes). Avoid eating grapefruit or drinking grapefruit juice while using Zocor unless your doctor instructs you otherwise. Do not start or stop any medicine without doctor or pharmacist approval.

Zocor Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: severe vomiting.

Zocor Notes

Do not share Zocor with others. Laboratory and/or medical tests (e.g., liver function or CK muscle tests) may be performed to monitor your progress, especially if you are taking 80 milligrams or more per day of simvastatin. For best results, Zocor should be used along with exercise and a low-cholesterol/low-fat diet. Consult your doctor.

Zocor Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Zocor Storage

Store Zocor at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture.


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